Detalhe da pesquisa
1.
In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy.
Antimicrob Agents Chemother
; 68(3): e0122223, 2024 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38265216
2.
Biophysical library screening using a Thermo-FMN assay to identify and characterize Clostridioides difficile FabK inhibitors.
Biochem Biophys Res Commun
; 705: 149740, 2024 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38458032
3.
Synthesis and evaluation of phenylimidazole FabK inhibitors as new Anti-C. Difficile agents.
Bioorg Med Chem
; 88-89: 117330, 2023 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37224699
4.
Concise Synthesis of Tunicamycinâ V and Discovery of a Cytostatic DPAGT1 Inhibitor.
Angew Chem Int Ed Engl
; 61(31): e202203225, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35594368
5.
Second-Generation Antidiabetic Sulfonylureas Inhibit Candida albicans and Candidalysin-Mediated Activation of the NLRP3 Inflammasome.
Antimicrob Agents Chemother
; 64(2)2020 01 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31712208
6.
Constitutive expression of the cryptic vanGCd operon promotes vancomycin resistance in Clostridioides difficile clinical isolates.
J Antimicrob Chemother
; 75(4): 859-867, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31873741
7.
Identification of Small Molecules Exhibiting Oxacillin Synergy through a Novel Assay for Inhibition of vraTSR Expression in Methicillin-Resistant Staphylococcus aureus.
Antimicrob Agents Chemother
; 63(9)2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31209003
8.
Crystal structure of the 65-kilodalton amino-terminal fragment of DNA topoisomerase I from the gram-positive model organism Streptococcus mutans.
Biochem Biophys Res Commun
; 516(2): 333-338, 2019 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31204053
9.
Rifamycin Resistance in Clostridium difficile Is Generally Associated with a Low Fitness Burden.
Antimicrob Agents Chemother
; 60(9): 5604-7, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27381389
10.
A simplified protocol for high-yield expression and purification of bacterial topoisomerase I.
Protein Expr Purif
; 124: 32-40, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27117979
11.
Comparison of radii sets, entropy, QM methods, and sampling on MM-PBSA, MM-GBSA, and QM/MM-GBSA ligand binding energies of F. tularensis enoyl-ACP reductase (FabI).
J Comput Chem
; 36(25): 1859-73, 2015 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-26216222
12.
Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI).
Bioorg Med Chem Lett
; 25(6): 1292-6, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25677657
13.
Evaluation of Fusobacterium nucleatum Enoyl-ACP Reductase (FabK) as a Narrow-Spectrum Drug Target.
ACS Infect Dis
; 10(5): 1612-1623, 2024 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38597503
14.
High-level expression, purification, and characterization of Staphylococcus aureus dihydroorotase (PyrC) as a cleavable His-SUMO fusion.
Protein Expr Purif
; 88(1): 98-106, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23246866
15.
Fragment-based drug discovery using a multidomain, parallel MD-MM/PBSA screening protocol.
J Chem Inf Model
; 53(3): 560-72, 2013 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23432621
16.
In vivo evaluation of Clostridioides difficile enoyl-ACP reductase II (FabK) Inhibition by phenylimidazole unveils a promising narrow-spectrum antimicrobial strategy.
bioRxiv
; 2023 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37790427
17.
Decoding a cryptic mechanism of metronidazole resistance among globally disseminated fluoroquinolone-resistant Clostridioides difficile.
Nat Commun
; 14(1): 4130, 2023 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37438331
18.
Expression, purification and characterization of enoyl-ACP reductase II, FabK, from Porphyromonas gingivalis.
Protein Expr Purif
; 85(1): 100-8, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22820244
19.
Identification of Dual-Target Compounds with Antifungal and Anti-NLRP3 Inflammasome Activity.
ACS Infect Dis
; 7(8): 2522-2535, 2021 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34260210
20.
Antibacterial kaneoheoic acids A-F from a Hawaiian fungus Fusarium sp. FM701.
Phytochemistry
; 181: 112545, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-33217722